Workshop A 09.00 – 12.00
Exploring Next-Generation CRISPR Delivery Systems to Overcome the Challenges Associated With LNPs & AAVs
Synopsis
Despite decades of research and investment into AAVs for gene editing delivery, and the rise of LNPs since the COVID-19 pandemic, critical bottlenecks for traditional delivery systems remain. As trailblazing industry and academic leaders look to capitalize on this booming industry, keep updated on the next wave of delivery systems set to revolutionize the industry.
This hands-on session will cover:
- Designing novel delivery systems, such as the Feldan Peptide Shuttle and extracellular vesicles to ensure your choice of delivery system is fit for purpose
- Examining how these can enable you to deliver more complex payloads
- Overcoming manufacturing challenges of novel delivery systems to streamline and reduce scale-up costs
Lunch
Workshop B 13.00 – 16.00
Pre-Empting CMC Challenges in Discovery: Uncovering When & How Gene Editing Delivery Process Development Should Be Considered to Prevent ScaleUp Becoming a Bottleneck
Synopsis
With scale up and CMC considerations being critical for bringing a new drug to market at speed, it is critical to understand at what point CMC should be considered in the selection, development, and engineering of novel gene editing systems.
Dive deep into:
- Understanding the stage at which process development can be considered and how to carry out predictive modelling to reduce development timelines
- Visualizing what scaled-up manufacturing of gene editing systems would look like to meet patient demand
- Selecting appropriate equipment for each stage of process development to maximize cost-effectiveness and efficiency
